Mansour was born in Al-Mansoura. He obtained his BA in philosophy in 1947 and started his journalistic career that year by joining the staff of the newspaper Al-Asas, later joining many other newspapers and magazines such as Rose_al-Yousef and Al-Ahram. In 1976, he became the editor in chief of the magazines Akher_Sa'a and 'October'.
Anis wrote more than 170 books on many subjects, some of which were translated into French, Dutch and Russian. He translated about 200 short stories and more than 20 plays into Arabic. He introduced Alberto Moravia to the Arabic literature by being the first to translate his works.